The Definitive Guide For Cannabis
And CBD Usage!

“CannabisMD.com is the Authority on Medical Cannabis and CBD. We strive to provide the most comprehensive and research backed information resource in the world.”

NEWSLETTER

DID YOU KNOW ?

YOUR BODY TYPE CAN DETERMINE
HOW CANNABIS AFFECTS YOU.

A larger individual may consume a lot more THC before feeling the effects. THC is stored in fat cells within body. [1]

A small person will not need a high dosage of THC due to low body fat and a high metabolism as the ‘high’ may hit faster. [2]

An 86 year old with Parkinson’s may use edibles to help cope. A dosage will last longer in elderly people with a slower metabolism. [3]

Yes, even your pets can benefit from CBD. Many pet owners use CBD to help with seizures, anxiety and other ailments. [4]

USAGE GUIDE RECOMMENDATIONS

01

Decide how you want to take cannabis

Cannabis oil is available in sprays, capsules, edibles and other forms.

02

Find your ratio.

Find the proper combination of THC and CBD to optimize your therapeutic use of cannabis.

03

Start with a low dose

Especially if you have little or no experience with cannabis.

04

Take a few small doses

over the course of the day rather than one big dose. This will allow your body to gradually get used to the effects slowly.

05

Don’t overdo it

“Less is more” is a good rule of thumb for cannabis therapeutics.

06

Be aware of possible side effects.

Cannabis is a safe medicine. But depending upon delivery method and individual tolerance, it can amplify anxiety and mood disorders. Other side effects may include dry mouth, dizziness and faintness.

07

Consult your health counselor.

Proceed cautiously, especially if you have a history of alcohol or drug abuse, mental illness, are pregnant or breastfeeding, or are taking other medications.

08

Use the same dose and ratio

Observe the effects and, if necessary, adjust the ratio or amount. Everyone is different and your experience may differ that of others.


ORAL DOSAGE RECOMENDATIONS

Experience Dosage
THC levels
Dosage
CBD levels
Beginner 1-10mg 12-18mg
Intermidate 11-20mg 18-25mg
Moderate 21-65mg 25-35mg
Expert 66mg 35+ mg

Please Keep In Mind

If you are a beginner and would like to try baked goods (Gastro-intestinal methods) i.e. cookies, brownies, pastries etc… be sure to find some that are relatively low in THC/CBD content. The dosage reccomendation guide is meant to help you determine an effective level for THC/CBD absorption in your body. Because THC/CBD absorbed gastrointestinally is the most effective absorption method, it is more potent and has a longer duration, therefore use your best judgement based on the dosage level guide above.

DELIVERY ROUTES

The best delivery methods for absorption of THC and CBD are listed below.

Method of delivery to the blood stream

  • Oral

  • Sublingual

  • Inhalation

  • Gastro Intestinal

  • Suppository

  • 0%
  • 20%
  • 40%
  • 60%
  • 80%

Percentage of THC absorbed

What is Cannabis Bio-availability?

Drug absorption happens almost entirely in the small intestine. The stomach serves as a reservoir that releases partially digested food into the small intestine at a steady rate. Consuming a meal will slow gastric emptying and limit movement of the drug to the small intestine where it can be absorbed. One study has shown that THC itself slows the rate of gastric emptying by half

Drugs must be in a solution to be absorbed, they cannot be absorbed in a solid state. If a drug has low solubility, it will take a longer amount of time to be absorbed into the bloodstream. THC and other cannabinoids have very low solubility in water since they are highly lipophilic meaning they are attracted to fats and lipids. However, eating a meal causes the gallbladder to release bile acids which helps to solubilize cannabinoids such as THC. This generally increases the rate and extent of absorption

Permeability is the ability of a molecule to cross a lipid (fat) membrane. Permeability depends on things like molecule size, charge, and lipophilicity. Higher permeability is better for drug absorption. [10,36]

Suppositories offer an ideal choice for those undergoing chemotherapy, elderly and babies who are unable to smoke or swallow pills. Suppository effects are long lasting, and can range between 4-8 hours depending on the person’s physiology and cannabis tolerance. The medicinal compounds in suppositories are absorbed into the bloodstream through the intestinal wall and therefore is the best form of administration available and effectively removes most of the ‘high.’ [11]

START LOW AND GO SLOW

What You Eat Can Interact with THC and CBD Absorption

The results of a bioavailability study show the blood concentration ratio to be 2.8x higher for THC and 4.1x higher for CBD after a meal has been consumed. [10,19]

After food has been ingested, the total THC:CBD ratio is about 3:1 at the time of peak blood concentration which is already relatively high. However, this ratio after fasting was almost 9:1 – nearly 3 times higher than after a meal. [10]

Ratio of Total THC to CBD

  • 0.0
  • 2.5
  • 5.0
  • 7.5
  • 10.0
With Food
Without Food

So eating a cannabis edible on an empty stomach, even if it contains a 1:1 ratio of THC to CBD is the equivalent of smoking a cannabis strain with a 9:1 THC to CBD ratio

‘Start Low And Go Slow’ Take cannabis edibles after a solid meal. Expect that peak concentrations will not be reached until 4 hours later, although this can differ depending on the person

This study also revealed that if you are taking edibles mainly for the CBD content, you should definitely eat a meal first. This can boost CBD absorption 4 times higher. [10,19]

ABSORPTION (BIOAVAILABILITY)

  • The foods listed below are known to increase your ‘high.’ If you are attempting to eat food to reduce your ‘high,’ avoid these foods. [13]
    Mangoes Nuts Herbs & Spices Broccoli Sweet Potatos Tea Beer

    Refer to the columns to the right to find out how those specific foods affect the way THC is absorbed by the body.

  • Fats / Lipids
    Nuts Avacado Olive Oil Coconut Oil
    Fats / Lipids

    The amount of lipids present in cannabis-containing foods, or following a high-fat meal, is sufficient to activate intestinal lymphatic transport and lead to increased systemic exposure to cannabinoids. [12]

  • Protiens
    Fish Poultry Beef Eggs
    Protiens

    Your body relies on amino acids, the building blocks of protein, to create dopamine. When consumed with cannabis, meat can improve mood, decrease stress and increase feelings of euphoria because of the excess dopamine release. [14]

  • Carbohydrates
    Vegetables Bread Pasta Cereal
    Carbohydrates

    The bioavailability of macronutrients such as carbohydrates, proteins, and fats is usually very high at more than 90% of the macronutrients ingested. Carbohydrates that contain high levels of Vitamin E can allow a more enjoyable ‘high’ by boosting mood elevating molecules. [15]

  • Sugars
    Fruits Honey Syrup Refined Sugar
    Sugars

    The terpene called myrcene (found in mangos) speeds up the onset and extends the duration of a high by helping cannabinoidspass through the Blood Brain Barrier. [16]

SUBLINGUAL CONSUMPTION

Sublingual cannabis products like tinctures, lozenges, gummy candies and drinks provide a more efficient means of absorption because they can bypass the whole digestive tract and enter directly into the bloodstream via the highly permeable oral cavity. [17]

Typical dose recommendation is usually as little as a drop or two (i.e. 1-2 mg) that takes effect typically within 15-20 minutes because extracts are being absorbed through the oral cavity directly into the bloodstream. [18,7]

GASTROINTESTINAL CONSUMPTION

Cannabinoid absorption via the gastrointestinal tract can only occur once the product has reached the small intestine and liver. It can take up to 2 hours to fully reach your bloodstream but don’t take them on an empty stomach. The THC attaches to fat cells in your stomach content and exponentially increases its absorption of the cannabinoids. Also, keep in mind eating a large meal will slow the absorption rate. [18]

TOPICAL APPLICATION

Topical cannabis uses a thick oil that has been decarboxylated to activate cannabinoids. Once cannabinoids have been activated, they can be absorbed through your skin.

Topical effects differ from other methods as they don’t provide the cerebral stimulation that creates the ‘high.’ Because of this, topicals are appropriate for consumers needing a clear head and localized relief (i.e. for example, muscle aches or soreness). [22,7]

INHALATION

When cannabis is inhaled, the gases enter the lungs before being absorbed into the bloodstream. The two primary ways to inhale are: smoking and vaping. [27].

Below are some commonly used methods to inhale cannabis:

SMOKING VS. EATING

Smoking cannabis can offer predictable results and is easier to control. Edibles can cause intense ‘highs’ that are less predictable. [32,33]

Smoking takes 2-10 minutes to start feeling the effects.
Oral ingestion can take 15-90 minutes to kick in

Smoked

Smoking cannabis has a much quicker effect and does not last nearly as long

Orally consumed

Allow anywhere from 15 – 90 minutes to start feeling the effects of ingested cannabis. It will take effect slower but last much longer.

‘SLOW YOUR ROLL’

Ways To Reduce Your Buzz

There is no way to eliminate your ‘high’ completely but there are ways to reduce it. If you find yourself struggling with overconsumption and need to sober up, these tips may help get you back on track. [34] If these methods do not work refer to the Emergency Guide on page 18 and consult your doctor

CBD

CBD works by blocking THC from binding with the cannabinoid receptors in your brain, toning down the effects from THC. [34]

Hydrate

Water is a great way to detoxify your body, so drink lots of it. Cranberry or orange juice also work well. [34]

Exercise

Exercise is one of the best ways to sober up in a hurry because it causes a release of endorphins in the brain and relieves the stress of your excessive ‘high.’ [34]

Take a nap

A quick nap may do the trick. Allow yourself 30 minutes to rest and find somewhere comfortable and away from distractions. [34].

Eat Something

Food can bring you down from a ‘high.’ [34]Be sure to avoid foods that can elevate the ‘high’ by referring to the Absorption Chart on Pg. 11

Cold Shower

This works because cold water triggers an immediate decreased heart rate. It will drop your temperature, preserve excess oxygen and in turn, THC. [34]


EMERGENCY GUIDE

  1. If it is a serious emergency call 911.
  2. If you have any health concerns call your doctor.
  3. Panic attacks can happen with too much THC. Calming down with a cold shower or excercise can help
  4. Stop cannabis consumption until you feel calm and in a secure state of mind.